Intrascrotal nodules in adult men as a marker for filarial granuloma in a bancroftian filariasis-endemic area.
Identifieur interne : 006227 ( Main/Exploration ); précédent : 006226; suivant : 006228Intrascrotal nodules in adult men as a marker for filarial granuloma in a bancroftian filariasis-endemic area.
Auteurs : Joaquim Nor Es [Brésil] ; José Figueredo-Silva ; Gerusa DreyerSource :
- The American journal of tropical medicine and hygiene [ 1476-1645 ] ; 2009.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Brésil (épidémiologie), Diéthylcarbamazine (usage thérapeutique), Filaricides (usage thérapeutique), Filariose lymphatique (anatomopathologie), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Granulome (anatomopathologie), Humains, Jeune adulte, Maladies endémiques, Mâle, Scrotum (anatomopathologie), Études rétrospectives.
- MESH :
- anatomopathologie : Filariose lymphatique, Granulome, Scrotum.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- épidémiologie : Brésil, Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Humains, Jeune adulte, Maladies endémiques, Mâle, Études rétrospectives.
- Wicri :
- geographic : Brésil.
English descriptors
- KwdEn :
- Adolescent, Adult, Brazil (epidemiology), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (pathology), Endemic Diseases, Filaricides (therapeutic use), Granuloma (pathology), Humans, Male, Middle Aged, Retrospective Studies, Scrotum (pathology), Young Adult.
- MESH :
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- geographic , epidemiology : Brazil.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- pathology : Elephantiasis, Filarial, Granuloma, Scrotum.
- Adolescent, Adult, Endemic Diseases, Humans, Male, Middle Aged, Retrospective Studies, Young Adult.
Abstract
A retrospective study was undertaken in Recife, Brazil to evaluate the specificity of intrascrotal nodules detected by physical examination as a marker of dead or degenerating adult Wuchereria bancrofti worms (filarial granuloma). A total of 372 nodules from 340 adult male patients (mean age 23.1 years) were studied. Of those, 253 (68%) nodules were from 226 patients treated with antifilarial drugs (Group 1) and 119 (32%) nodules were considered non-drug related and were obtained from 114 patients (Group 2). On histologic examination, all nodules from Group 1 and all but one (99.1%) from Group 2 contained degenerated or dead adult worms. In the one case without filarial granuloma, ectopic cortical adrenal tissue was found in the spermatic cord. These findings emphasize the high specificity of intrascrotal nodules for bancroftian granuloma and draw attention to the importance of examining the scrotal contents of young men in studies of antifilarial drug efficacy. These findings also have potential implications for bancroftian filariasis control programs.
PubMed: 19635891
Affiliations:
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Aged</term><term>Retrospective Studies</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Humains</term><term>Jeune adulte</term><term>Maladies endémiques</term><term>Mâle</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Brésil</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A retrospective study was undertaken in Recife, Brazil to evaluate the specificity of intrascrotal nodules detected by physical examination as a marker of dead or degenerating adult Wuchereria bancrofti worms (filarial granuloma). A total of 372 nodules from 340 adult male patients (mean age 23.1 years) were studied. Of those, 253 (68%) nodules were from 226 patients treated with antifilarial drugs (Group 1) and 119 (32%) nodules were considered non-drug related and were obtained from 114 patients (Group 2). On histologic examination, all nodules from Group 1 and all but one (99.1%) from Group 2 contained degenerated or dead adult worms. In the one case without filarial granuloma, ectopic cortical adrenal tissue was found in the spermatic cord. These findings emphasize the high specificity of intrascrotal nodules for bancroftian granuloma and draw attention to the importance of examining the scrotal contents of young men in studies of antifilarial drug efficacy. These findings also have potential implications for bancroftian filariasis control programs.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>Pernambuco</li></region></list><tree><noCountry><name sortKey="Dreyer, Gerusa" sort="Dreyer, Gerusa" uniqKey="Dreyer G" first="Gerusa" last="Dreyer">Gerusa Dreyer</name><name sortKey="Figueredo Silva, Jose" sort="Figueredo Silva, Jose" uniqKey="Figueredo Silva J" first="José" last="Figueredo-Silva">José Figueredo-Silva</name></noCountry><country name="Brésil"><region name="Pernambuco"><name sortKey="Nor Es, Joaquim" sort="Nor Es, Joaquim" uniqKey="Nor Es J" first="Joaquim" last="Nor Es">Joaquim Nor Es</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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